Atractylodis Macrocethalae.P.E
Atactylodis macrocethalae.P.E
CAS: 142223-62-9
Molecular Formula: C40H47F2N3O2
Atractylodis Macrocethalae.P.E - Names and Identifiers
Atractylodis Macrocethalae.P.E - Physico-chemical Properties
| Molecular Formula | C40H47F2N3O2 |
| Molar Mass | 639.82 |
Atractylodis Macrocethalae.P.E - References
| plant extract | Atractylodes macrocephala Koidz extract is the rhizome extract of Atractylodes lancea, the main components are volatile components, lactones, glycosides, polysaccharides and amino acids. With Spleen qi, dampness and water, antiperspirant, the effect of tocolysis, commonly used in spleen deficiency, abdominal distension, diarrhea, phlegm, dizziness, edema, spontaneous sweating, fetal agitation and other symptoms. This information was compiled by Shi Yan. |
| source plant | the main source is the rhizome of atractylodes rhizome of Atractylodes lancea. [alias] Mountain Thistle, Yang Yi Thistle, Shu, mountain mustard, Sky Thistle, mountain Ginger, killiga, mountain essence, Mountain Union, winter atractylodes. [morphology] perennial herb, 20-60cm in height, with nodular rhizome. Stems upright, middle-lower part of branches, all smooth and hairless. The middle leaf has a petiole of 3-6cm in length, the leaf blade is usually 3-5 Featherly fully split, the lateral lobes are 1-2 pairs, inverted-genus, oval or oblong, 4.5-7cm in length, width: 1.5 ~ 2cm, the apical lobe was larger than the lateral lobe, long-oval, long-oval or oval; From middle up or down, the leaves became smaller, dividing equally with the middle lobe, the leaves immediately below the inflorescence do not divide, oval or oblong. Larger capitulum, single shoot tip, usually 6-10; Bract Green, length 3 ~ 4cm, needle-like plumage full-split; Involucre broad bell-shaped, 3 ~ 4cm in diameter, involucre 7~10 layers, lined, outer layer and middle layer long-ovoid or triangular, middle layer in the shape of a circle or oval-shaped, the innermost layer is broadly linear, apical purple-red, all bract apical blunt, margin white spider hair; Flowers tubular, purple-red. Achenes inverted conical, densely anterograde; Crown bristles, featherlike, stained white, base bound to ring-like. Flower and Fruit period 8~10 months. [Habitat and distribution] on the slope of grassland or forest. Zhejiang, Jiangxi, Hunan, Sichuan and other places have wild distribution; Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Hubei, Hunan, Sichuan have cultivated. Cultivation is also available in Japan. Figure 1 shows Atractylodes macrocephala |
| Chemical composition | volatile oil: the main components in the oil are Atractylon (Atractylon), Atractylol (Atractylol), atractylone A(Butenolide A), B(Butenolide B), 3-β-acetoxyatractylon, 3-β-hydroxy-atractylon, [Selina-4(14),7(11)-dien-8-one], sesquiterpene (C15H22O). There are various acylation products of atractylodes triol (Tetradeca-2,8,10-trien-4,6-diene-1,12,14-triol): There are 12-α-methyl butyryl-14-acetyl-2E,8Z,10E-cis-atractylodes triol, 12-α-methylbutyryl-14-acetyl-2E,8E,10E-trans-atractylodes triol, 14-α-methylbutyryl-2e, 8Z,10E-cis-atractylodes triol, 14-α-methylbutyryl-2e, 8E,10E-trans-atractylodes Triol. |
| pharmacological action | 1. Diuretic effect of Baizhu decoction, liquid extract gavage or intravenous injection, on rats, rabbits, dogs, etc. have diuretic effect, oral administration also has obvious diuretic effect. Atractylodes macrocephala decoction 0.05~0.25g/kg, the dog intravenous injection of 0.5~1 hours after the start of diuresis, 2 hours to the peak, continued for 1.5 hours, the average urine volume increased by 9.2 times, intragastric administration of 1~3g/kg, urine volume increased 2~6 times, and most of the drug in 6~7 hours after still more than normal, atractylodes not only increase water excretion, it also promotes the excretion of electrolytes, particularly sodium. Sodium excretion increased 35.2 times, chlorine excretion, urinary CO2 capacity, pH value and potassium excretion increased in varying degrees. 2. Hypoglycemic effect of rabbit gavage decoction or infusion, blood glucose decreased slightly, rats gavage decoction, can accelerate the assimilation of glucose in the body and thus reduce the role of blood sugar. 3. Anti-blood coagulation effect of rats daily perfusion decoction 0.5g/kg, a total of 1~4 weeks, the prothrombin time was significantly prolonged, the root of the stem, healthy people take root decoction (1: 20), 1 tbsp, 3 times a day. After 4 days, the prothrombin time and clotting time were significantly prolonged, and more than 10 days after drug withdrawal, they returned to normal, ethanol leaching solution also has the effect, but the maintenance time is short. 4. Immune enhancement effect of Atractylodes macrocephala decoction can obviously improve the phagocytic function of peritoneal macrophages in mice, so that the cells become larger and more phagocytic, and the nuclei become smaller. Studies have shown that Atractylodes macrocephala can significantly increase the number of TH cells in immunocompromised mice, increase the ratio of TH/TS, correct the disorder of the distribution of TC cell subsets, and significantly increase the low level of IL-2, and can increase the expression of T lymphocyte surface IL-2R, which may be an important mechanism of immune enhancement and immune regulation of Atractylodes macrocephala. 5. Animal experiments show that Atractylodes macrocephala has obvious antioxidant effect, can effectively reduce lipid peroxidation, reduce the content of LPO, can avoid the damage of harmful substances on the structure and function of tissue cells, in addition, there is a tendency to increase SOD activity, enhance the body's ability to scavenge free radicals, and reduce the damage of free radicals to the body. 6. Tocolysis effect of Atractylodes macrocephala Koidz alcohol extract and petroleum ether extract on non-pregnant mice in vitro spontaneous uterine contraction and oxytocin, motherwort induced uterine excitability contraction showed significant inhibitory effect, and with the increase of drug concentration and inhibition of enhanced, there is a dose-effect relationship. The alcohol extract of Atractylodes macrocephala also completely antagonized the tonic contraction of oxytocin on the pregnant uterus of guinea pigs in vivo. The inhibitory effect of water extract on the isolated uterus was weak. 7. Other effects of Baizhu decoction can increase animal weight and muscle strength, have a strong effect; Have increased the role of leukopenia caused by radiotherapy or chemotherapy; Meningococcus, Bacillus anthracis, diphtheria bacilli, the fungi such as Bacillus subtilis and epidermal ringworm have inhibitory effect, inhibit the heart of Toad, and slow down the heart rate, inhibit the gastric emptying of rats, and promote the function of small intestine; the volatile oil of Atractylodes macrocephala has the sedative effect on the Golden Frog, and shows the anesthetic effect in a large dose; It has a significant inhibitory effect on Ehrlich ascites carcinoma. |
| identification | 【trait identification】 the rhizome exhibited a little fists-shaped mass, with enlargement of the lower two sides, hoof-shaped or "Ruyi head", commonly known as "cloud head", tapering up, often with residual stem base or Bud marks, commonly known as "Atractylodes macrocephala", 3 ~ 13cm in length, 1.5-7cm in diameter. The surface is gray-yellow or gray-brown, with irregular nodular protrusions or longitudinal wrinkles and furrows, and fibrous roots. Hard, not easy to break; Uneven cross-section, yellow-white or light brown, with scattered brownish-yellow punctiform oil Chamber. The section was light yellow in color, keratin-like, with sometimes central fissure. It has a clear smell. Sweet and slightly sticky. With a large section of yellow-white, solid, no hollow, no stem residues on the ground is better. [Microscopic identification] light yellow-brown powder. ① The stone cells are light yellow, round, rectangular to polygonal, about 35-65 μm in diameter. ② the fiber was yellow, mostly in bundles, long fusiform, 20~48 μm in diameter, thick-walled, wood-lined, with obvious holes and grooves, with thin wall. ③The calcium oxalate crystals were fine and irregularly gathered in the parenchyma cells. (4) the parenchyma cells contain inulin, and the surface has a radial texture. (5) The ductal molecules were short, with reticulate and marginal striated holes. [physical and chemical identification] take 0.5g of powder, add 2ml of n-hexane, ultrasonic extract for 15min, filter, filtrate as test solution. Another 0.5g of Atractylodes macrocephala Koidz was used as control medicine solution. 10 μl of each of the above-mentioned two kinds of solutions were absorbed, respectively, put on the same silica gel G thin layer plate, and developed with petroleum ether (60-90 ° C.)-ethyl acetate (50:1). Spray with 5% vanillin sulfuric acid solution, hot air blowing until the spots are clear. The chromatogram of the test sample shows spots of the same color at the same position as the chromatogram of the control medicinal material, and should show a pink spot. |
| efficacy | [sexual taste] bitter, sweet, warm. Meridian tropism: spleen and stomach Meridian. Function: Qi and spleen, dampness and water, antiperspirant, tocolysis. This product is sweet, warm, into the spleen and stomach, with good qi and spleen function; Bitter, warm, dampness and water, and for the treatment of spleen deficiency edema. Through invigorating Qi and strengthening spleen, the surface of the body to stop sweating, strong spleen, qi and blood, the fetus has to support and self-safe, so there is an effect of fetal safety. |
Last Update：2024-04-09 20:52:54
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